Professor Ivo Tews

Research interests

Natural products biosynthesis: a complex cascade of catalytic steps in vitamin B6 biosynthesis is characterised by structures or reaction intermediates in the large PLP syntase complexEdit

Bacterial biofilms: understanding of RedOx regulated phosphodiesterase activity in dispersal of biofilms to address chronic infections

Cancer immunology: together with Cancer Immunology at Southampton we use a structure based apporach in developing novel cancer therapie

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Ivo Tews uses crystallography to study molecular interactions. Particular intrests are in large dynamic macromolecular complexes and time resolved techniques. As a member of the CCP4 project for crystallographic software he chairs working group 2, and is engaged in Synchrotron Science at the Diamond Light Source and the EUropean Synchtrotron Radiation Facilty.

Publications

67 publications

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Matthew J. Rodrigues, Volker Windeisen, Yang Zhang, Gabriela Guédez, Stefan Weber, Marco Strohmeier, Jeremiah W. Hanes, Antoine Royant, Gwyndaf Evans, Irmgard Sinning, Steven E. Ealick, Tadhg P. Begley & Ivo Tews, 2017, Nature Chemical Biology, 13(3), 290-294

DOI:

Type: article

Jane Willoughby, Jordana Griffiths, Ivo Tews & Mark Cragg, 2017, Molecular Immunology, 83, 13-22

DOI:

Type: article

Dom Bellini, Sam Horrell, Andrew Hutchin, Curtis W Phippen, Richard W Strange, Yuming Cai, Armin Wagner, Jeremy S Webb, Ivo Tews & Martin A Walsh, 2017, Scientific Reports, 7, 42166

DOI:

Type: article

Jeremy Webb, Andrew James Hutchin, Dom Bellini, Sam Horrell, Curtis Phippen, Yuming Cai, Richard W. Strange, Armin Wagner, Martin A. Walsh & Ivo Tews, 2016, Acta Crystallographica Section A: Foundations and Advances, 72(Supplement 1), S39-S40

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Type: conference

Salah Mansour, Anna Tocheva, Chris Cave-Ayland, Moritz M. Machelett, Barbara Sander, Nikolai M. Lissin, Peter E. Molloy, Mark S. Baird, Gunthard Stubs, Nicolas W.J. Schroder, Ralf R. Schumann, Jorg Rademann, Anthony D. Postle, Bent K. Jakobsen, Ben G. Marshall, Rajendra Gosain, Paul Elkington, Tim Elliott, Chris-Kriton Skylaris, Jonathan W. Essex, Ivo Tews & Stephan D. Gadola, 2016, Proceedings of the National Academy of Sciences, 113(9), E1266-E1275

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Type: article

Ivo Tews & Jon Cooper, 2015, Acta Crystallographica Section D: Biological Crystallography, 71, 1-2

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Type: article

Curtis William Phippen, Halina Mikolajek, Henry George Schlaefli, Charles William Keevil, Jeremy Stephen Webb & Ivo Tews, 2014, FEBS Letters, 588(24), 4631-4636

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Type: article

Joanna Tripp, Alexander Hahn, Patrick Koenig, Nadine Flinner, Daniela Bublak, Eva M. Brouwer, Franziska Ertel, Oliver Mirus, Irmgard Sinning, Ivo Tews & Enrico Schleiff, 2012, The Journal of Biological Chemistry, 287(29), 24164-24173

DOI:

Type: article

Gabriela Guedez, Katharina Hipp, Volker Windeisen, Bianca Derrer, Martin Gengenbacher, Bettina Boettcher, Irmgard Sinning, Barbara Kappes & Ivo Tews, 2012, Structure, 20(1), 172-184

DOI:

Type: article

Barbara Kappes, Ivo Tews, Alexandra Binter & Peter Macheroux, 2011, Biochimica et Biophysica Acta (BBA) - Proteins & Proteomics, 1814(11), 1567-1576

DOI:

Type: article

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