EORTC 40983 Trial

Trial Name:

Pre and Post-operative chemotherapy with oxaliplatin 5FU/LV V surgery alone if resectable liver metastases from colorectal origin—Phase III study

Objectives:

Is pre- and post-operative chemotherapy with oxaliplatin plus 5FU/LV of benefit compared to surgery alone for patients with resectable liver metastases from colorectal origin?

Primary: Progression Free Survival
Secondary: Overall survival, Tumor resectability, Tumor response

Design:

Randomized multicenter, Phase III Clinical Trial

Status:

Complete

Population:

All potentially resectable liver metastases without detectable extra-hepatic tumor.
Primary tumor resected (R0 resection) or resectable (synchronous metastases).
No previous chemotherapy with oxaliplatin. Adjuvant chemotherapy for the primary cancer is allowed unless it contained oxaliplatin.

Publications:

Contact details:

All Trial enquiries should be addressed to ctu@soton.ac.uk

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